Description

Cyclobutane-1,2-Dicarboxylic Acid Dimethyl Ester, Trans CAS NO 3396-20-1 is a high-purity, trans-configured diester derivative of cyclobutane dicarboxylic acid. This compound serves as a versatile and valuable chemical building block and advanced pharmaceutical intermediate for complex organic synthesis. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing constrained ring systems and chiral molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) with cyclobutane cores, particularly for antiviral and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the rigid cyclobutane structure can enhance biological activity.
• Ligand and Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Monomer for producing specialty polyesters and polyamides with unique thermal and mechanical properties due to the strained ring.
• Organic Synthesis Building Block: Employed in Diels-Alder reactions, ring-opening polymerizations, and other transformations to introduce sterically defined, four-membered carbocycles.
• Fragrance and Flavor Chemistry: Intermediate for synthesizing musks and other complex aroma chemicals that benefit from its specific stereochemistry.

Basic Information

Product Name	Cyclobutane-1,2-Dicarboxylic Acid Dimethyl Ester, Trans
CAS No.	3396-20-1
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	trans-1,2-Cyclobutanedicarboxylic Acid Dimethyl Ester; Dimethyl trans-Cyclobutane-1,2-dicarboxylate; (1R,2R)-rel-1,2-Cyclobutanedicarboxylic Acid Dimethyl Ester; (1S,2S)-rel-1,2-Cyclobutanedicarboxylic Acid Dimethyl Ester; NSC 163045; Methyl trans-1,2-cyclobutanedicarboxylate; trans-Cyclobutane-1,2-dicarboxylic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Cyclobutane-1,2-Dicarboxylic Acid Dimethyl Ester, Trans is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Trans Isomer Content	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.