Description

4-(Bromomethyl)-1-Chloro-2-Nitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromomethyl, chloro, and nitro functional groups on a benzene ring, makes it a highly reactive intermediate for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functional handles for further derivatization.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the nitro and halogen substituents are crucial for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, dyes, and photoactive compounds.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent electrophile for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution Scaffold: The chloro and bromo groups provide distinct sites for sequential nucleophilic substitution, allowing for precise, stepwise functionalization.

Basic Information

Product Name	4-(Bromomethyl)-1-Chloro-2-Nitrobenzene
CAS No.	3360-45-0
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	1-Chloro-4-(bromomethyl)-2-nitrobenzene; 2-Nitro-4-(bromomethyl)chlorobenzene; 4-Bromomethyl-1-chloro-2-nitrobenzene; 2-Chloro-5-nitrobenzyl bromide; (2-Chloro-5-nitrophenyl)methyl bromide; NSC 403107; Benzene, 1-chloro-4-(bromomethyl)-2-nitro-
EINECS	222-128-8

Quality Control

Our 4-(Bromomethyl)-1-Chloro-2-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and elemental analysis to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or compatible light-blocking materials.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Individual impurity < 0.5%, Total impurities < 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.