Description

2,2′-Dde is a specialized chemical compound widely recognized for its role as a protective group in peptide synthesis and bioconjugation chemistry. Its primary value lies in its orthogonality, allowing for the selective deprotection of amino groups under mild conditions without affecting other sensitive functional groups. This makes it an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing complex peptides, antibodies, and other biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as an orthogonal protecting group for lysine and other amine-containing amino acids.
• Bioconjugation and Linker Chemistry: Facilitates the site-specific attachment of drugs, labels, or other molecules to proteins and antibodies.
• Combinatorial Chemistry: Enables the synthesis of diverse peptide libraries for drug discovery and screening.
• Glycopeptide Synthesis: Protects amine functionalities during the complex synthesis of glycosylated peptides.
• Antibody-Drug Conjugate (ADC) Development: A key building block for creating stable, cleavable linkers in targeted cancer therapies.
• Materials Science: Employed in the surface functionalization of nanomaterials and polymers for biomedical applications.

Basic Information

Product Name	2,2′-Dde
CAS No.	3328-98-1
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl; N-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl)-Dde-OH; 2,2′-Dimethyldiphenylether Derivative; Dde Protecting Group; Dde Reagent; N-1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethylidene; Fmoc-Lys(Dde)-OH (related derivative)
EINECS	Contact for details

Quality Control

Our 2,2′-Dde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.