Description

trans-Cyclobutane-1,2-Dicarbonitrile is a high-purity, versatile organic building block featuring a rigid cyclobutane ring with two nitrile groups in a trans configuration. This unique structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and advanced materials research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring constrained geometry and functional group diversity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring a conformationally restricted scaffold.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the cyclobutane core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal and mechanical properties.
• Chemical Research: Employed in academic and industrial R&D for [4+2] cycloaddition reactions and other cyclobutane ring-based transformations.
• Material Science: Investigated for use in the development of organic electronic materials and liquid crystals.

Basic Information

Product Name	trans-Cyclobutane-1,2-Dicarbonitrile
CAS No.	3211-20-9
Molecular Formula	C6H6N2
Molecular Weight	106.12 g/mol
Synonyms	(1R,2R)-1,2-Cyclobutanedicarbonitrile; (1S,2S)-1,2-Cyclobutanedicarbonitrile; trans-1,2-Cyclobutanedicarbonitrile; trans-1,2-Dicyanocyclobutane; rac-trans-1,2-Cyclobutanedicarbonitrile; Cyclobutane-1,2-dicarbonitrile, trans-; 1,2-Cyclobutanedicarbonitrile, (R*,R*)-(±)-
EINECS	221-732-5

Quality Control

Our trans-Cyclobutane-1,2-Dicarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
trans-Isomer Content (GC/HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.