Description

1R,2S-(-)-Norephedrine Hydrochloride is a high-purity chiral intermediate and active pharmaceutical ingredient (API) of significant commercial and research importance. Its defined stereochemistry is critical for applications requiring specific enantiomeric activity, ensuring predictable biological interactions and regulatory compliance. This compound is essential for manufacturers and research institutions in the pharmaceutical, fine chemical, and analytical reagent sectors.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of more complex active pharmaceutical ingredients (APIs) and decongestants.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Biochemical Research: Employed in studies of adrenergic receptors and as a tool compound in pharmacological research due to its stereospecific activity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or resolving agent in the production of enantiomerically pure compounds.
• Veterinary Pharmaceuticals: Potential use in the formulation of specific veterinary medicinal products.

Basic Information

Product Name	1R,2S-(-)-Norephedrine Hydrochloride
CAS No.	3198-15-0
Molecular Formula	C9H14ClNO
Molecular Weight	187.66 g/mol
Synonyms	(-)-Norephedrine Hydrochloride; (1R,2S)-(-)-Norephedrine HCl; l-Norephedrine Hydrochloride; (1R,2S)-2-Amino-1-phenyl-1-propanol Hydrochloride; (-)-Threo-2-Amino-1-phenyl-1-propanol Hydrochloride; Cathine Hydrochloride; Norpseudoephedrine Hydrochloride; (1R,2S)-Norephedrine Hydrochloride
EINECS	221-719-6

Quality Control

Our 1R,2S-(-)-Norephedrine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and strength. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing specifications such as assay, enantiomeric excess, and impurity profiles. The product is suitable for use under cGMP conditions for pharmaceutical development and meets the standards required for use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.