Description

D-Alanine, n-1-(Trifluoroacetyl)-L-Prolyl-, Methyl Ester is a specialized chiral building block and protected amino acid derivative. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis laboratories for developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and APIs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce specific D-amino acid residues with orthogonal protecting groups.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and proteomics research.
• Asymmetric Synthesis: Employed as a building block in the asymmetric synthesis of complex organic molecules requiring high enantiomeric purity.
• Protease Inhibitor Development: Useful in the design and synthesis of protease inhibitors due to its prolyl and alanine motifs.
• Material Science: Potential use in creating specialized polymers and biomaterials with tailored properties.

Basic Information

Product Name	D-Alanine, n-1-(Trifluoroacetyl)-L-Prolyl-, Methyl Ester
CAS No.	3183-70-8
Molecular Formula	C11H15F3N2O4
Molecular Weight	296.24 g/mol
Synonyms	N-[(2S)-1-Oxo-2-pyrrolidinylmethyl]-N-(trifluoroacetyl)-D-alanine methyl ester; (R)-2-((S)-1-(Trifluoroacetyl)pyrrolidine-2-carboxamido)propanoic acid methyl ester; Methyl N-[(2S)-1-oxo-2-pyrrolidinylmethyl]-N-(trifluoroacetyl)-D-alaninate; D-Ala-N-Tfa-L-Pro-OMe; Tfa-L-Pro-D-Ala-OMe; N-(Trifluoroacetyl)-L-prolyl-D-alanine methyl ester; L-Prolyl-D-alanine derivative; Protected dipeptide ester
EINECS	Contact for details

Quality Control

Our D-Alanine, n-1-(Trifluoroacetyl)-L-Prolyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee reproducible quality and supply reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.