Description

2-Bromo-5-Nitrothiazole is a versatile and highly functionalized heterocyclic building block. This compound matters for its role as a key synthetic intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development teams in fine chemical synthesis, medicinal chemistry, and material science.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs containing the thiazole core.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals and organic semiconductors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and hit-to-lead optimization for new drug candidates.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig couplings.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of specialized dyes and colorants.

Basic Information

Product Name	2-Bromo-5-Nitrothiazole
CAS No.	3034-48-8
Molecular Formula	C3HBrN2O2S
Molecular Weight	208.99 g/mol
Synonyms	2-Bromo-5-nitro-1,3-thiazole; 5-Nitro-2-bromothiazole; Thiazole, 2-bromo-5-nitro-; NSC 403697; 2-Bromonitrothiazole; 2-Bromo-5-nitro-thiazole; 2-Bromo-5-nitro-δ⁴-thiazoline
EINECS	221-222-4

Quality Control

Our 2-Bromo-5-Nitrothiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.