Description

Ethyl 2,3,3,3-Tetrafluoropropionate is a high-value fluorinated ester building block, prized for its role in introducing the tetrafluoropropionate moiety into complex molecules. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where specific fluorine substitution patterns are required for enhanced properties. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those requiring fluorinated side chains to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where fluorine atoms enhance biological activity and environmental persistence.
• Fluorinated Polymer & Material Science: Serves as a monomer or modifier in the development of specialty polymers with improved chemical resistance, thermal stability, and surface properties.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric fluids.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the -CF2CF3 group via esterification or transesterification reactions in fine chemical production.

Basic Information

Product Name	Ethyl 2,3,3,3-Tetrafluoropropionate
CAS No.	399-92-8
Molecular Formula	C5H6F4O2
Molecular Weight	174.10 g/mol
Synonyms	Ethyl Tetrafluoropropionate; 2,3,3,3-Tetrafluoropropionic Acid Ethyl Ester; Ethyl Perfluoropropionate; Ethyl 3,3,3-Trifluoro-2-(trifluoromethyl)propanoate (incorrect but common); E2TFP; ETFPO; NSC 9235; Propanoic acid, 2,3,3,3-tetrafluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2,3,3,3-Tetrafluoropropionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.320 - 1.340
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.