Description

4-(Trifluoromethyl)-Biphenyl is a high-purity fluorinated aromatic compound, serving as a versatile and critical building block in advanced chemical synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which enhances lipophilicity, metabolic stability, and electronic characteristics in target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group improves bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core structure or side-chain modifier in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials.
• Polymer & Specialty Chemicals: Incorporated into polymers to modify thermal stability, chemical resistance, and surface properties for high-performance coatings and engineering plastics.
• Chemical Research & Development: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Stille) and as a standard in analytical method development for fluorinated compounds.

Basic Information

Product Name	4-(Trifluoromethyl)-Biphenyl
CAS No.	398-36-7
Molecular Formula	C₁₃H₉F₃
Molecular Weight	222.21 g/mol
Synonyms	4-(Trifluoromethyl)biphenyl; 4-Trifluoromethylbiphenyl; [1,1'-Biphenyl]-4-yl(trifluoro)methane; p-Trifluoromethylbiphenyl; 4-Phenylbenzotrifluoride; 4-Biphenylyltrifluoromethane; (4-Trifluoromethylphenyl)benzene; NSC 404083
EINECS	206-915-8

Quality Control

Our 4-(Trifluoromethyl)-Biphenyl is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent lot-to-lot performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.