Description

2,4,6-Trimethylfluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides steric hindrance and electronic effects crucial for developing specialty chemicals and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries seeking to introduce fluorine atoms into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry for creating analogs with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the fluorine atom enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and electronic materials to modify solubility and electronic properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the activated fluorine atom.
• Chemical Reference Standard: Acts as a pure standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	2,4,6-Trimethylfluorobenzene
CAS No.	392-69-8
Molecular Formula	C9H11F
Molecular Weight	138.18 g/mol
Synonyms	1-Fluoro-2,4,6-trimethylbenzene; Fluoromesitylene; Mesityl fluoride; 2,4,6-Trimethyl-1-fluorobenzene; Trimethylfluorobenzene; F-Mesitylene
EINECS	206-879-6

Quality Control

Our 2,4,6-Trimethylfluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	0.980 - 1.010 g/mL
Refractive Index (n20/D)	1.485 - 1.495

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.