Description

2-(Trifluoroacetyl)Cyclohexanone is a versatile fluorinated organic building block, specifically a trifluoroacetyl-substituted cyclic ketone. This compound is valued for its unique reactivity profile, where the electron-withdrawing trifluoroacetyl group significantly activates the adjacent carbonyl and alpha positions. It serves as a critical synthetic intermediate for researchers and process chemists developing novel compounds in high-value sectors. Key industrial applications include its use in advanced pharmaceutical synthesis, agrochemical development, and the creation of specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, or receptor binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve pesticidal activity and environmental persistence.
• Organic Synthesis Building Block: Employed in various name reactions and cyclization processes to construct complex heterocyclic and carbocyclic frameworks common in fine chemicals.
• Material Science Research: Acts as a monomer or modifying agent in the development of fluorinated polymers and advanced organic materials with specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Useful for synthesizing novel chiral ligands or metal-organic complexes used in asymmetric catalysis.

Basic Information

Product Name	2-(Trifluoroacetyl)Cyclohexanone
CAS No.	387-89-3
Molecular Formula	C8H9F3O2
Molecular Weight	194.15 g/mol
Synonyms	2-Trifluoroacetylcyclohexanone; 1-(2-Oxocyclohexyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-oxocyclohexyl)ethanone; Cyclohexanone, 2-(trifluoroacetyl)-; α-Trifluoroacetylcyclohexanone; TFACH; 2-TFA-cyclohexanone
EINECS	206-869-6

Quality Control

Every batch of 2-(Trifluoroacetyl)Cyclohexanone is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and specification adherence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.