Description

5-(Trifluoromethyl)-2H-3,1-Benzoxazine-2,4(1H)-Dione, 5-(Trifluoromethyl)-1H-Benzo[D][1,3]Oxazine-2,4-Dione CAS NO 387-18-8 is a high-value, fluorinated heterocyclic building block characterized by its benzoxazinedione core and trifluoromethyl substituent. This compound is essential for its role as a versatile synthetic intermediate in advanced organic chemistry, enabling the introduction of the metabolically stable and lipophilic trifluoromethyl group into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

This specialized chemical intermediate serves critical functions in several high-tech sectors:

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental stability.
• Material Science Research: Employed in the creation of novel fluorinated polymers, liquid crystals, and organic electronic materials with unique properties.
• Organic Synthesis Building Block: Facilitates complex molecular construction in medicinal and process chemistry for lead optimization and library synthesis.
• Chemical Biology Probes: Acts as a scaffold for developing enzyme inhibitors and molecular probes used in biochemical research.

Basic Information

Product Name	5-(Trifluoromethyl)-2H-3,1-Benzoxazine-2,4(1H)-Dione, 5-(Trifluoromethyl)-1H-Benzo[D][1,3]Oxazine-2,4-Dione
CAS No.	387-18-8
Molecular Formula	C9H4F3NO3
Molecular Weight	231.13 g/mol
Synonyms	5-(Trifluoromethyl)-1H-3,1-benzoxazine-2,4-dione; 5-(Trifluoromethyl)-2H-1,3-benzoxazine-2,4(1H)-dione; 5-Trifluoromethyl-2H-3,1-benzoxazine-2,4(1H)-dione; 5-Trifluoromethyl-1H-3,1-benzoxazine-2,4-dione; 5-Trifluoromethylbenzoxazinedione; 1H-Benzo[d][1,3]oxazine-2,4-dione, 5-(trifluoromethyl)-; NSC 403107; 387-18-8
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-2H-3,1-Benzoxazine-2,4(1H)-Dione adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.