Description

2-Chloro-2,2-difluoroacetophenone is a versatile and high-purity fluorinated building block essential for advanced organic synthesis. This compound matters because its unique difluoromethyl ketone structure enables the introduction of critical fluorine atoms and reactive handles into target molecules, enhancing their metabolic stability and binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require fluorinated aromatic segments.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to incorporate the -COCF2Cl moiety into complex molecules.
• Fluorine Chemistry Research: A valuable standard and starting material in academic and industrial R&D focused on organofluorine chemistry.

Basic Information

Product Name	2-Chloro-2,2-difluoroacetophenone
CAS No.	384-67-8
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	α,α-Difluoro-α-chloroacetophenone; 2,2-Difluoro-2-chloroacetophenone; Phenacyl Chlorodifluoride; 2-Chloro-1-phenylethane-1,1-dione; (Chlorodifluoroacetyl)benzene; 1-Chloro-1,1-difluoroacetophenone; Chlorodifluoroacetylbenzene
EINECS	206-851-3

Quality Control

Our 2-Chloro-2,2-difluoroacetophenone is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.