Description

2-Fluoroethyl 4-Methylbenzenesulfonate is a versatile organofluorine building block and sulfonate ester of significant interest in advanced organic synthesis. This compound matters for its role as a key alkylating agent, enabling the efficient introduction of the 2-fluoroethyl moiety into target molecules, which is a critical modification in medicinal chemistry and materials science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules and developing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine-containing side chains to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides where the 2-fluoroethyl group can enhance biological activity and environmental persistence.
• Fluorinated Material Precursor: Acts as a monomer or building block for creating specialty polymers, liquid crystals, and electronic materials with unique dielectric and surface properties.
• Radiochemistry & PET Tracer Development: Employed as a precursor for synthesizing fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging agents.
• Cross-Coupling & Functionalization Reactions: Utilized in palladium-catalyzed cross-coupling and other metal-mediated reactions to create complex molecular architectures.
• Bioconjugation & Probe Synthesis: Facilitates the labeling of biomolecules (peptides, proteins, nucleic acids) with fluorinated tags for biochemical and diagnostic applications.

Basic Information

Product Name	2-Fluoroethyl 4-Methylbenzenesulfonate
CAS No.	383-50-6
Molecular Formula	C9H11FO3S
Molecular Weight	218.25 g/mol
Synonyms	2-Fluoroethyl p-Toluenesulfonate; Tosyloxyethyl Fluoride; 4-Methylbenzenesulfonic Acid 2-Fluoroethyl Ester; p-Toluenesulfonic Acid 2-Fluoroethyl Ester; 2-Fluoroethyl Tosylate; 1-Fluoro-2-[(4-methylphenyl)sulfonyloxy]ethane; 2-Fluoroethyl 4-Toluenesulfonate; 2-Fluoroethyl Tosylate Ester
EINECS	206-849-4

Quality Control

Our 2-Fluoroethyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material and can support regulatory filings with detailed documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.