Description

3-Hydroxy-2-Trifluoromethylpropionic Acid is a versatile fluorinated organic acid building block, valued for its unique combination of a carboxylic acid group, a hydroxyl group, and a trifluoromethyl moiety. This trifunctional structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where fluorine substitution is desired to modulate properties like metabolic stability, lipophilicity, and bioavailability. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel fluorinated active pharmaceutical ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides with enhanced activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers used in electronic display technologies.
• Polymer Modification: Incorporates fluorine into polymer backbones to improve chemical resistance, thermal stability, and surface properties.
• Complex Ligand & Catalyst Synthesis: Employed in creating specialized chiral ligands and organocatalysts for asymmetric synthesis.
• Peptide Mimetics & Bio-conjugates: Useful for introducing fluorinated side chains into peptide analogs to study protein interactions and improve stability.

Basic Information

Product Name	3-Hydroxy-2-Trifluoromethylpropionic Acid
CAS No.	382-43-4
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	2-(Trifluoromethyl)-3-hydroxypropanoic acid; 3-Hydroxy-2-(trifluoromethyl)propanoic acid; β-Hydroxy-β-trifluoromethylpropionic acid; 3-Hydroxy-2-trifluoromethylpropanoic acid; 2-Trifluoromethyl-3-hydroxypropionic acid; 3-Hydroxy-2-(trifluoromethyl)propionic acid; 382-43-4; NSC 163082
EINECS	206-848-5

Quality Control

Our 3-Hydroxy-2-Trifluoromethylpropionic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can provide materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.