Description

1,1,1-Trifluoro-3-Methyl-Butan-2-One is a versatile fluorinated ketone building block prized for its unique reactivity and physicochemical profile. This compound is essential for introducing the trifluoromethyl group into complex molecules, a key modification for enhancing metabolic stability and lipophilicity in advanced materials. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from novel drug synthesis to the development of advanced polymers and electronic materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric trifluoromethyl group to improve drug-like properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine incorporation enhances biological activity and environmental persistence.
• Specialty Polymer & Resin Modifier: Serves as a monomer or cross-linking agent to create fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated liquid crystals and organic semiconductors for display technologies and electronic devices.
• Organic Synthesis Reagent: Acts as a versatile electrophile in nucleophilic addition reactions and as a precursor for various fluorinated heterocycles and complex organic frameworks in academic and industrial research.
• Solvent & Reaction Medium: Utilized as a specialty fluorinated solvent for demanding chemical reactions and separation processes due to its specific solvation properties.

Basic Information

Product Name	1,1,1-Trifluoro-3-Methyl-Butan-2-One
CAS No.	382-03-6
Molecular Formula	C5H7F3O
Molecular Weight	140.10 g/mol
Synonyms	3-Methyl-1,1,1-trifluorobutan-2-one; 1,1,1-Trifluoro-3-methylbutan-2-one; 3-Methyl-1,1,1-trifluoro-2-butanone; TFMBK; Trifluoroacetyl isopropyl; Isopropyl trifluoroacetate (common misnomer); 2-Propanone, 1,1,1-trifluoro-3-methyl-
EINECS	206-843-5

Quality Control

Our 1,1,1-Trifluoro-3-Methyl-Butan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.345 - 1.355
Density (20°C)	1.15 - 1.25 g/mL
Boiling Point	Approx. 85-90°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.