Description

Difluoroacetic Acid is a versatile fluorinated organic acid with the CAS registry number 381-73-7, valued for its unique reactivity as a building block in advanced chemical synthesis. Its incorporation of fluorine atoms imparts distinct electronic and steric properties, making it a critical intermediate for creating high-value, performance-driven compounds. This product is essential for research and industrial applications in the pharmaceutical, agrochemical, and specialty materials sectors where precise fluorination is required.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring a difluoromethyl or difluoromethylene group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and polymerization reactions.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving material properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the difluoroacetyl group into target molecules through esterification, amidation, or other coupling reactions.
• Electrolyte Additive Research: Investigated for use in lithium-ion battery electrolytes to improve stability and performance at high voltages.

Basic Information

Product Name	Difluoroacetic Acid
CAS No.	381-73-7
Molecular Formula	C2H2F2O2
Molecular Weight	96.03 g/mol
Synonyms	2,2-Difluoroacetic Acid; DFA; Difluoroethanoic Acid; DFAc; α,α-Difluoroacetic Acid; NSC 5291; UN 3265
EINECS	206-842-2

Quality Control

Our Difluoroacetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including assay by titration, gas chromatography (GC) for purity and impurity profiling, and identity confirmation by FT-IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your technical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and corrosive nature, containers must be kept tightly sealed and upright. Recommended storage temperature is 2-8°C to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0 %
Water Content (KF)	≤ 0.5 %
Related Substances (GC)	Monofluoroacetic Acid: ≤ 0.1 % Trifluoroacetic Acid: ≤ 0.5 %
Density (at 20°C)	1.50 - 1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.