Description

1-Bromo-2-Chloro-1,1,2-Trifluoro-3-Butene is a halogenated alkene building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and fluorine substituents, makes it a versatile intermediate for constructing complex fluorinated molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to introduce fluorinated motifs, which are critical for modulating the biological activity, metabolic stability, and physical properties of target compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for introducing trifluoromethyl and related fluorinated groups.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination enhances efficacy and environmental persistence.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of specialty polymers with unique chemical resistance, thermal stability, or surface properties.
• Organic Electronics: Investigated as a precursor for materials used in organic light-emitting diodes (OLEDs) and semiconductors due to the influence of halogens on electronic properties.
• Liquid Crystal & Display Technology: Employed in the synthesis of fluorinated liquid crystal compounds for high-performance displays.
• Refrigerant & Propellant Research: Studied as a potential component or intermediate in next-generation fluorocarbon-based fluids.
• Cross-Coupling Reactions: The bromine and chlorine atoms provide handles for selective metal-catalyzed coupling reactions (e.g., Suzuki, Negishi) to build complex architectures.
• Chemical Research & Development: A valuable tool for academic and industrial researchers exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	1-Bromo-2-Chloro-1,1,2-Trifluoro-3-Butene
CAS No.	374-25-4
Molecular Formula	C4H3BrClF3
Molecular Weight	211.42 g/mol
Synonyms	1-Bromo-2-chloro-1,1,2-trifluorobut-3-ene; 3-Butene, 1-bromo-2-chloro-1,1,2-trifluoro-; BCTFB; 1,1,2-Trifluoro-1-bromo-2-chloro-3-butene; (Z)-1-Bromo-2-chloro-1,1,2-trifluorobut-3-ene; (E)-1-Bromo-2-chloro-1,1,2-trifluorobut-3-ene; Halogenated butene intermediate; Bromochlorotrifluorobutene
EINECS	206-787-2

Quality Control

Our 1-Bromo-2-Chloro-1,1,2-Trifluoro-3-Butene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key specifications and test results. Our quality commitment ensures material integrity for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Isomer Ratio (GC)	Reported on COA
Water Content (KF)	≤ 0.5%
Non-volatile Residue	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.