Description

2,2,3,3,3-Pentafluoropropylamine Hydrochloride is a high-value organofluorine building block, specifically the hydrochloride salt of a pentafluoropropyl-substituted amine. This compound is critical for introducing the unique physicochemical properties of fluorine into advanced molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine atoms can enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides, herbicides, and fungicides to improve efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or modifier in the production of specialty polymers, coatings, and surfactants with enhanced oil- and water-repellency (oleophobic/hydrophobic properties).
• Liquid Crystal & Electronic Chemicals: Employed in the development of fluorinated components for display technologies and electronic materials.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for 18F-labeled radiopharmaceuticals for medical imaging.
• Cross-coupling Reactions: Acts as a substrate in palladium-catalyzed amination (Buchwald-Hartwig) and other cross-coupling reactions to create complex amines.

Basic Information

Product Name	2,2,3,3,3-Pentafluoropropylamine Hydrochloride
CAS No.	374-14-1
Molecular Formula	C3H5ClF5N
Molecular Weight	185.52 g/mol
Synonyms	1-Amino-2,2,3,3,3-pentafluoropropane Hydrochloride; 2,2,3,3,3-Pentafluoro-1-propanamine Hydrochloride; 3,3,3-Trifluoro-2-(trifluoromethyl)propylamine Hydrochloride; Pentafluoropropylamine HCl; 2,2,3,3,3-Pentafluoropropan-1-amine Hydrochloride
EINECS	206-787-9

Quality Control

Our 2,2,3,3,3-Pentafluoropropylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.