Description

Chloromethanesulfonyl Fluoride is a versatile organosulfur fluorinating reagent and a key synthetic intermediate. Its primary value lies in its ability to act as a sulfonyl fluoride precursor, enabling the introduction of the sulfonyl fluoride moiety into target molecules, which is critical for applications in medicinal chemistry and materials science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing sulfonamide-based drugs, covalent inhibitors, and advanced polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of biologically active sulfonamides and sulfonyl fluorides used in drug discovery programs.
• Covalent Inhibitor Development: Serves as a precursor for creating sulfur(VI) fluoride exchange (SuFEx) click chemistry probes and covalent enzyme inhibitors.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides and fungicides containing the sulfonyl fluoride functional group.
• Polymer & Materials Science: Used to modify polymer chains and surfaces, introducing functional groups for advanced material properties.
• Organic Synthesis Reagent: Employed as a fluorinating and sulfonylating agent in complex multi-step synthetic routes.
• Chemical Biology Tool: Facilitates the study of protein function and interaction through activity-based protein profiling (ABPP).

Basic Information

Product Name	Chloromethanesulfonyl Fluoride
CAS No.	373-93-3
Molecular Formula	CH2ClFO2S
Molecular Weight	132.54 g/mol
Synonyms	Chloromethylsulfonyl fluoride; CMSF; Methanesulfonyl fluoride, chloro-; Chloromethanesulfonylfluorid; (Chloromethyl)sulfonyl fluoride; NSC 88582; 1-Chloro-1-fluoromethanesulfonic acid (anhydride)
EINECS	206-775-5

Quality Control

Our Chloromethanesulfonyl Fluoride is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.