Description

Ethyl 4,4,4-Trifluoroacetoacetate is a versatile fluorinated β-ketoester building block, prized for introducing the trifluoromethyl group into complex molecular architectures. Its high reactivity and the unique properties imparted by fluorine make it an essential intermediate in advanced synthesis. This compound is primarily sought after by the pharmaceutical, agrochemical, and specialty chemical industries for research and production.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing the trifluoromethyl group, which enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine atoms improve efficacy and environmental profile.
• Fluorinated Heterocycle Construction: Serves as a precursor for pyrazoles, isoxazoles, and other nitrogen-containing heterocycles important in medicinal and material chemistry.
• Ligand and Catalyst Development: Employed in the synthesis of fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Used to create fluorinated polymers and advanced organic electronic materials with tailored properties.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new fluorination methodologies and compound libraries.

Basic Information

Product Name	Ethyl 4,4,4-Trifluoroacetoacetate
CAS No.	372-31-6
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	Ethyl Trifluoroacetoacetate; 4,4,4-Trifluoro-3-oxobutanoic Acid Ethyl Ester; 3-Oxo-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-3-oxobutanoate; TFAAE; Acetoacetic Acid, 4,4,4-Trifluoro-, Ethyl Ester; Ethyl 3-Oxo-4,4,4-trifluorobutanoate; Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester
EINECS	206-751-2

Quality Control

Our Ethyl 4,4,4-Trifluoroacetoacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.380 - 1.390
Density (20°C)	1.28 - 1.32 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.