Description

Ethyl 3-Amino-4,4,4-Trifluorocrotonate is a versatile fluorinated organic building block, crucial for introducing the trifluoromethyl group and an amino-crotonate moiety into complex molecular architectures. Its primary value lies in enabling the synthesis of high-value, biologically active compounds, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers in medicinal chemistry, crop protection, and advanced material science who require a reliable, high-purity intermediate for constructing novel molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and other advanced materials with unique thermal and chemical resistance properties.
• Organic Synthesis Reagent: Employed in various name reactions (e.g., Michael additions, cyclocondensations) to construct complex heterocycles and fine chemicals.
• Fluorine Chemistry Research: An important reagent for academic and industrial R&D focused on exploring the effects of fluorine substitution in organic molecules.

Basic Information

Item	Details
Product Name	Ethyl 3-Amino-4,4,4-Trifluorocrotonate
CAS No.	372-29-2
Molecular Formula	C6H8F3NO2
Molecular Weight	183.13 g/mol
Synonyms	Ethyl 3-Amino-4,4,4-trifluorobut-2-enoate; 4,4,4-Trifluoro-3-aminocrotonic Acid Ethyl Ester; 3-Amino-4,4,4-trifluorocrotonic Acid Ethyl Ester; Ethyl (Z)-3-Amino-4,4,4-trifluorocrotonate; ATFC; 3-Amino-4,4,4-trifluoro-2-butenoic Acid Ethyl Ester
EINECS	206-758-6

Quality Control

Our Ethyl 3-Amino-4,4,4-Trifluorocrotonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, from research and development to pilot and commercial-scale production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its sensitivity to light and moisture, containers should be kept sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.