Description

Ethyl 3-Bromo-4,4,4-Trifluorobutyrate is a versatile fluorinated organic building block of significant importance in advanced chemical synthesis. Its molecular structure, featuring both bromine and trifluoromethyl groups, makes it a critical intermediate for introducing fluorinated segments into target molecules, which is a key strategy in modern pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex, high-value molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylated butyrate backbone.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and electronic materials that benefit from fluorine's unique properties.
• Cross-Coupling Reactions: The bromine atom acts as a handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form new carbon-carbon bonds.
• Nucleophilic Substitution: The ester and halogen functionalities allow for further derivatization to create a diverse library of fluorinated compounds for screening.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D labs for methodology development and exploring new fluorination pathways.

Basic Information

Product Name	Ethyl 3-Bromo-4,4,4-Trifluorobutyrate
CAS No.	372-27-0
Molecular Formula	C6H8BrF3O2
Molecular Weight	225.03 g/mol
Synonyms	3-Bromo-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 3-Bromo-4,4,4-trifluorobutanoate; 4,4,4-Trifluoro-3-bromobutanoic Acid Ethyl Ester; Butanoic acid, 3-bromo-4,4,4-trifluoro-, ethyl ester; Ethyl γ-Bromo-β,β,β-trifluorobutyrate
EINECS	206-761-5

Quality Control

Our Ethyl 3-Bromo-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is between 2°C and 8°C for extended stability, although the product is stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.