Description

3-Fluoropropyl-1-Methanesulfonate is a versatile and reactive organofluorine building block, also known by its CAS number 372-04-3. This compound is valued for its role as a key intermediate in the synthesis of more complex fluorinated molecules, which are critical in advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing fluoropropyl groups into target structures.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and potential drug candidates, leveraging the unique properties of fluorine to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for creating fluorinated polymers, liquid crystals, or surface modifiers with specific chemical resistance or low surface energy properties.
• PET Tracer Development: Acts as a key reagent in the synthesis of fluorinated precursors for Positron Emission Tomography (PET) imaging agents, particularly those containing the [18F] fluoride isotope.
• Organic Synthesis & Methodology: Employed in academic and industrial research as a model substrate for developing new fluorination reactions or studying reaction mechanisms involving sulfonate esters.
• Ligand and Catalyst Preparation: Utilized to introduce fluorinated alkyl chains into ligands or organocatalysts to fine-tune their electronic properties and solubility.

Basic Information

Product Name	3-Fluoropropyl-1-Methanesulfonate
CAS No.	372-04-3
Molecular Formula	C4H9FO3S
Molecular Weight	156.18 g/mol
Synonyms	1-Fluoro-3-(methylsulfonyloxy)propane; 3-Fluoropropyl methanesulfonate; 1-Fluoro-3-methanesulfonyloxypropane; Methanesulfonic acid 3-fluoropropyl ester; 3-FPM; 3-Fluoropropan-1-yl methanesulfonate; 3-Fluoropropyl mesylate; 3-FPMs
EINECS	206-751-4

Quality Control

Our 3-Fluoropropyl-1-Methanesulfonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.