Description

4-Fluorobutyric Acid 2-Chloroethyl Ester is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. This bifunctional compound is valued for its reactivity, offering both an electrophilic chloroethyl group and a fluorinated alkyl chain. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification Agent: Employed to introduce fluorinated side chains into polymers, altering surface properties like hydrophobicity, oleophobicity, and chemical resistance.
• Cross-coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes for preparing complex fluorinated compounds in academic and industrial research laboratories.

Basic Information

Product Name	4-Fluorobutyric Acid 2-Chloroethyl Ester
CAS No.	371-28-8
Molecular Formula	C6H10ClFO2
Molecular Weight	168.59 g/mol
Synonyms	2-Chloroethyl 4-Fluorobutanoate; 4-Fluorobutanoic Acid 2-Chloroethyl Ester; 2-Chloroethyl 4-Fluorobutyrate; Ethanol, 2-chloro-, 4-fluorobutanoate; 4-Fluorobutyric Acid β-Chloroethyl Ester; β-Chloroethyl 4-Fluorobutyrate; Butanoic acid, 4-fluoro-, 2-chloroethyl ester
EINECS	206-742-5

Quality Control

Our 4-Fluorobutyric Acid 2-Chloroethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory requirements for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. Containers should be kept tightly sealed when not in use to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.430 - 1.440
Density	1.18 - 1.22 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.