Description

Ethyl 4,4,4-Trifluorobutyrate is a versatile fluorinated ester building block, prized for its trifluoromethyl group which imparts unique physicochemical properties to target molecules. This compound is essential for introducing lipophilicity and metabolic stability in advanced chemical synthesis. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, enhancing bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine moiety improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Reagent: Acts as a versatile reagent in nucleophilic addition and condensation reactions for constructing complex organic frameworks.
• Flavor & Fragrance Intermediate: Employed in the synthesis of specialty aroma chemicals, leveraging the ester functionality.
• Polymer Modification: Used to introduce fluorine into polymer chains, modifying surface properties, chemical resistance, and durability.

Basic Information

Product Name	Ethyl 4,4,4-Trifluorobutyrate
CAS No.	371-26-6
Molecular Formula	C6H9F3O2
Molecular Weight	170.13 g/mol
Synonyms	4,4,4-Trifluorobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluorobutanoate; Butanoic Acid, 4,4,4-Trifluoro-, Ethyl Ester; Ethyl γ,γ,γ-Trifluorobutyrate; NSC 9235; 371-26-6; Ethyl Perfluorobutyrate (common name)
EINECS	206-739-3

Quality Control

Our Ethyl 4,4,4-Trifluorobutyrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.365 - 1.375
Density (20°C)	1.190 - 1.230 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.