Description

4-Fluorothioanisole is a versatile fluorinated aromatic sulfide building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a thioether group, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and novel crop protection agents. The reliable supply of high-purity 4-Fluorothioanisole CAS NO 371-15-3 is essential for accelerating innovation in these high-value industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the synthesis of charge-transport materials and semiconductors for OLEDs and other electronic devices.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to introduce the 4-fluorophenylthio moiety.
• Flavor & Fragrance Industry: Utilized as a precursor for synthesizing specific sulfur-containing aromatic compounds.
• Chemical Research: A valuable reagent for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	4-Fluorothioanisole
CAS No.	371-15-3
Molecular Formula	C7H7FS
Molecular Weight	142.19 g/mol
Synonyms	1-Fluoro-4-(methylthio)benzene; p-Fluorothioanisole; 4-(Methylthio)fluorobenzene; (4-Fluorophenyl)(methyl)sulfide; Methyl 4-fluorophenyl sulfide; 4-Fluorophenyl methyl sulfide; p-Fluorophenyl methyl sulfide
EINECS	206-740-7

Quality Control

Our 4-Fluorothioanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.18 - 1.22 g/mL
Refractive Index (n20D)	1.550 - 1.560

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.