Description

4-Fluoro-3-Methylacetophenone is a versatile fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which combines a reactive acetyl group with fluorine and methyl substituents on the aromatic ring, enabling precise chemical modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Fine Chemical & Specialty Polymer Manufacturing: Employed in the synthesis of complex fragrance compounds, dyes, and specialty polymers that benefit from the introduction of fluorine.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling reactions, fluorination chemistry, and the exploration of new chemical spaces in medicinal chemistry.

Basic Information

Product Name	4-Fluoro-3-Methylacetophenone
CAS No.	369-32-4
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(4-Fluoro-3-methylphenyl)ethanone; 4'-Fluoro-3'-methylacetophenone; 3-Methyl-4-fluoroacetophenone; 4-Fluoro-m-methylacetophenone; 1-Acetyl-4-fluoro-3-methylbenzene; p-Fluoro-m-methylacetophenone; 369-32-4; Ethanone, 1-(4-fluoro-3-methylphenyl)-
EINECS	206-724-3

Quality Control

Our 4-Fluoro-3-Methylacetophenone is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.