Description

2',4'-Difluoroacetophenone is a versatile fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which profoundly influences the electronic and steric properties of downstream molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders, anti-inflammatory agents, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluoro motif enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial R&D for constructing complex fluorinated molecules and exploring new catalytic transformations.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.

Basic Information

Product Name	2',4'-Difluoroacetophenone
CAS No.	364-83-0
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	1-(2,4-Difluorophenyl)ethanone; 2,4-Difluoroacetophenone; 2,4-DFAP; Ethanone, 1-(2,4-difluorophenyl)-; 2,4-Difluorophenyl methyl ketone; α,2,4-Trifluoroacetophenone (incorrect but sometimes used); 2',4'-Difluoroacetophenone
EINECS	206-669-8

Quality Control

Our 2',4'-Difluoroacetophenone is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for manufacturing, ensuring reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.