Description

4-(Trifluoroacetyl)Morpholine is a versatile fluorinated organic building block characterized by its morpholine ring and reactive trifluoroacetyl group. This compound is highly valued in advanced organic synthesis for its ability to introduce the trifluoroacetyl moiety, a key functional group that can modulate the physicochemical properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated components for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers and advanced materials with unique surface properties and chemical resistance.
• Peptide Modification: Useful for introducing fluorinated ketone functionalities into peptides and peptidomimetics for biochemical and medicinal chemistry studies.

Basic Information

Product Name	4-(Trifluoroacetyl)Morpholine
CAS No.	360-95-2
Molecular Formula	C6H8F3NO2
Molecular Weight	183.13 g/mol
Synonyms	N-(Trifluoroacetyl)morpholine; Morpholine, 4-(trifluoroacetyl)-; 2-(Trifluoroacetyl)morpholine; 4-Trifluoroacetylmorpholine; 4-Morpholinecarboxylic acid, trifluoro-, anhydride; Trifluoroacetic acid morpholide; N-Trifluoroacetylmorpholine
EINECS	206-634-6

Quality Control

Our 4-(Trifluoroacetyl)Morpholine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.