Description

5,5,5-Trifluoropentan-2-ol is a valuable fluorinated alcohol building block, distinguished by its trifluoromethyl group which imparts unique physicochemical properties. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after intermediate in advanced synthesis. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Polymer & Surface Modifier: Incorporated into specialty polymers and coatings to alter surface energy, providing oil, water, and stain repellency.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to introduce the -CH(CF3)CH2OH functional group into complex organic frameworks.
• Solvent & Co-solvent for Specialty Reactions: Acts as a polar, fluorinated solvent for reactions requiring unique solvation properties or temperature stability.

Basic Information

Product Name	5,5,5-Trifluoropentan-2-ol
CAS No.	352-58-9
Molecular Formula	C5H9F3O
Molecular Weight	142.12 g/mol
Synonyms	5,5,5-Trifluoro-2-pentanol; 2-Pentanol, 5,5,5-trifluoro-; 5,5,5-Trifluoropentanol-2; 1,1,1-Trifluoro-4-pentanol; 4,4,4-Trifluorobutyl methanol; 2-Hydroxy-5,5,5-trifluoropentane; 5,5,5-Trifluoroamyl alcohol
EINECS	206-522-8

Quality Control

Every batch of 5,5,5-Trifluoropentan-2-ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at room temperature for shorter periods. The container must be kept tightly sealed due to the compound's sensitivity to moisture (hygroscopic).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.365 - 1.375
Density (g/mL at 20°C)	1.20 - 1.25

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.