Description

1-Fluoro-4-Iodobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working in life sciences, material science, and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aryl groups.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings due to the reactive iodine moiety.
• Fluorination Chemistry Studies: Used as a model compound in research exploring the effects of fluorine substitution on aromatic systems.
• Ligand and Catalyst Preparation: Employed in the synthesis of sophisticated ligands for catalysis and molecular recognition.

Basic Information

Product Name	1-Fluoro-4-Iodobenzene
CAS No.	352-34-1
Molecular Formula	C6H4FI
Molecular Weight	221.99 g/mol
Synonyms	p-Fluoroidobenzene; 4-Fluoro-1-iodobenzene; 4-Fluoroidobenzene; 1-Iodo-4-fluorobenzene; p-Iodofluorobenzene; 4-Iodofluorobenzene; F-C6H4-I
EINECS	206-522-6

Quality Control

Our 1-Fluoro-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.