Description

3'-(Trifluoromethyl)Acetophenone is a versatile aromatic ketone building block characterized by its trifluoromethyl substituent, which imparts unique electronic and steric properties. This compound is essential for introducing the metabolically stable and lipophilic trifluoromethyl group into target molecules, significantly enhancing their biological activity and physicochemical profile. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF₃ group improves efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials for electronic displays.
• Functional Polymer Monomer: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis: A valuable substrate in cross-coupling reactions, carbonyl chemistry, and as a ligand precursor in organometallic catalysis.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic methodologies and developing novel fluorinated compounds.

Basic Information

Product Name	3'-(Trifluoromethyl)Acetophenone
CAS No.	349-76-8
Molecular Formula	C₉H₇F₃O
Molecular Weight	188.15 g/mol
Synonyms	1-[3-(Trifluoromethyl)phenyl]ethanone; 3-Acetylbenzotrifluoride; m-(Trifluoromethyl)acetophenone; 3'-Trifluoromethylacetophenone; 3-(Trifluoromethyl)phenyl methyl ketone; 3-Trifluoromethylacetophenone; Ethanone, 1-[3-(trifluoromethyl)phenyl]-; α,α,α-Trifluoro-m-acetophenone
EINECS	206-500-9

Quality Control

Our 3'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Refractive Index (n20/D)	1.460 - 1.470
Density (g/mL at 20°C)	1.25 - 1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.