Description

1-Fluoro-2-Iodobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on the benzene ring, makes it a critical intermediate for constructing complex molecules via cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, enabling the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated aryl moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and stability.
• Material Science: Serves as a building block for liquid crystals, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent leaving group for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings to form biaryl structures.
• Fluorination Studies: Used as a model substrate in methodological development for nucleophilic aromatic substitution and other fluorination techniques.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries.

Basic Information

Product Name	1-Fluoro-2-Iodobenzene
CAS No.	348-52-7
Molecular Formula	C6H4FI
Molecular Weight	221.99 g/mol
Synonyms	2-Fluoroiodobenzene; o-Fluoroiodobenzene; 1-Iodo-2-fluorobenzene; 2-Iodofluorobenzene; (2-Fluorophenyl)iodide; Benzene, 1-fluoro-2-iodo-; Fluorobenzene, 2-iodo-
EINECS	206-485-5

Quality Control

Our 1-Fluoro-2-Iodobenzene is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, assay, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. The compound is sensitive to light and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~2.0 g/mL
Boiling Point	~ 85-87°C / 15 mmHg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.