Description

4'-Nitro-3-(trifluoromethyl)-1,1'-biphenyl is a specialized biphenyl derivative featuring both nitro and trifluoromethyl functional groups, making it a valuable intermediate in advanced organic synthesis. This compound is crucial for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique structure enables the introduction of key pharmacophores. It is primarily sought by research and development chemists, process development teams, and manufacturers in fine chemical and life science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting specific receptor sites where the trifluoromethyl and nitro groups enhance binding and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where its biphenyl core contributes to the compound's efficacy and environmental profile.
• Material Science Research: Acts as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, aromatic structure and functional handles for further modification.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodological studies, such as cross-coupling reactions and functional group transformations, to explore new synthetic pathways.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of complex organic dyes and pigments, where the nitro group is often a key chromophore component.

Basic Information

Product Name	4'-Nitro-3-(trifluoromethyl)-1,1'-biphenyl
CAS No.	346-99-6
Molecular Formula	C₁₃H₈F₃NO₂
Molecular Weight	267.21 g/mol
Synonyms	3-(Trifluoromethyl)-4'-nitrobiphenyl; 1,1'-Biphenyl, 4'-nitro-3-(trifluoromethyl)-; 4'-Nitro-3-trifluoromethylbiphenyl; 3-Trifluoromethyl-4'-nitrobiphenyl; [1,1'-Biphenyl]-4'-carbonitrile, 3'-(trifluoromethyl)-; 4-Nitro-3'-(trifluoromethyl)biphenyl
EINECS	Contact for details

Quality Control

Our production of 4'-Nitro-3-(trifluoromethyl)-1,1'-biphenyl adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity limits is provided with every shipment. We support compliance with global regulatory frameworks, and specifications can be aligned with customer-specific requirements for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere such as nitrogen or argon to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.