Description

1,1'-(Bromomethylene)Bis(4-Fluorobenzene) is a specialized fluorinated organic building block featuring a bromomethylene bridge. This compound is valued for its unique bifunctional reactivity, serving as a versatile intermediate in advanced synthetic chemistry. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), especially those requiring fluorinated or diarylmethane motifs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the fluorobenzene groups enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in organometallic chemistry and catalysis.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and polymers.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1,1'-(Bromomethylene)Bis(4-Fluorobenzene)
CAS No.	345-90-4
Molecular Formula	C14H9BrF2
Molecular Weight	295.12 g/mol
Synonyms	Bis(4-fluorophenyl)bromomethane; α-Bromo-4,4'-difluorodiphenylmethane; (Bromomethylene)bis(4-fluorobenzene); 4,4'-Difluorobenzhydryl bromide; 1,1-Bis(4-fluorophenyl)-1-bromomethane; p,p'-Difluorobenzhydryl bromide; Bromodifluorodiphenylmethane
EINECS	Contact for details

Quality Control

Our 1,1'-(Bromomethylene)Bis(4-Fluorobenzene) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.