Description

2'-Methyl-2,2,2-Trifluoroacetophenone is a versatile fluorinated aromatic ketone building block, valued for its trifluoromethyl group which imparts unique electronic and steric properties to target molecules. This compound is essential for the synthesis of advanced intermediates in pharmaceutical and agrochemical research, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity. It serves as a critical precursor for medicinal chemists and process development scientists in the fine chemical and life science industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylated aromatic motifs to enhance drug potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials due to its fluorine content.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and developing new methodologies in synthetic organic chemistry.

Basic Information

Product Name	2'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	341-39-9
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	2-Methyl-α,α,α-trifluoroacetophenone; 1-(2-Methylphenyl)-2,2,2-trifluoroethanone; 2-Methylphenyl trifluoromethyl ketone; o-Methyl-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(2-methylphenyl)ethanone; 1-(o-Tolyl)-2,2,2-trifluoroethanone; 2'-Methyl-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.