Description

1-(4-Chlorophenyl)-2-Fluoroethanone is a versatile fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, enabling the introduction of both chlorophenyl and fluoroacetyl functional groups. Industries that need it include pharmaceutical R&D for creating novel active ingredients, agrochemical manufacturers for crop protection agents, and specialty chemical producers for liquid crystal and polymer precursors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the fluorinated moiety.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Polymer & Material Science: Employed in the synthesis of specialty monomers and polymers to impart specific chemical resistance or optical properties.
• Organic Synthesis Reagent: Acts as a versatile electrophile in Friedel-Crafts acylation and nucleophilic substitution reactions for laboratory and scale-up processes.
• Chemical Research: Utilized in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Item	Detail
Product Name	1-(4-Chlorophenyl)-2-Fluoroethanone
CAS No.	329-78-2
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	4'-Chloro-2-fluoroacetophenone; 2-Fluoro-1-(4-chlorophenyl)ethanone; p-Chloro-α-fluoroacetophenone; 1-(4-Chlorophenyl)-2-fluoroethan-1-one; 4-Chlorophenacyl fluoride; 2-Fluoro-4'-chloroacetophenone; α-Fluoro-4-chloroacetophenone; NSC 403697
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-2-Fluoroethanone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.