Description

n-(Trifluoroacetyl)-L-Ala-L-Phe-OMe is a protected dipeptide derivative, a crucial building block in advanced organic synthesis. This compound matters for its role in facilitating the controlled construction of complex peptide chains, where the trifluoroacetyl (TFA) group acts as a versatile protecting group for the amine functionality. Pharmaceutical researchers and fine chemical manufacturers need it for the development of peptide-based drugs, bioactive compounds, and as a key intermediate in solid-phase peptide synthesis (SPPS) workflows.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the sequential assembly of custom peptide sequences.
• Biochemical Research: Serves as a substrate or intermediate in enzymatic studies and the investigation of peptide structure-activity relationships (SAR).
• Proteomics & Labeling Reagents: Potential use in the development of chemical probes, tags, or mass spectrometry standards for protein analysis.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules requiring selective amine protection.
• Academic & R&D Laboratories: Essential for methodological development in organic chemistry and peptide science.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Ala-L-Phe-OMe
CAS No.	329-36-2
Molecular Formula	C16H19F3N2O5
Molecular Weight	376.33 g/mol
Synonyms	N-(Trifluoroacetyl)-L-alanyl-L-phenylalanine methyl ester; L-Alanine, N-[(trifluoroacetyl)-, L-phenylalanine methyl ester; N-TFA-L-Ala-L-Phe-OMe; Trifluoroacetyl-L-alanyl-L-phenylalanine methyl ester; Methyl N-(trifluoroacetyl)-L-alanyl-L-phenylalaninate; (S)-Methyl 2-((S)-2-(2,2,2-trifluoroacetamido)propanamido)-3-phenylpropanoate; TFA-Ala-Phe-OMe; Ala-Phe(OMe)-TFA
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Ala-L-Phe-OMe is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.