Description

4-Fluoro-β-Hydroxy-Phenylalanine is a fluorinated derivative of the amino acid phenylalanine, incorporating both fluorine and a hydroxyl group on the aromatic ring. This unique structural modification makes it a valuable non-natural amino acid building block for advanced pharmaceutical research and peptide synthesis. It is primarily utilized by research institutions and manufacturers in the life sciences sector for developing novel therapeutic agents and biochemical probes. The compound's specific stereochemistry and functional groups are critical for modulating the biological activity and metabolic stability of peptide-based drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system and metabolic disorder treatments.
• Peptide Synthesis: Used as a specialized amino acid residue in solid-phase and solution-phase peptide synthesis to introduce fluorine atoms, enhancing peptide stability and bioavailability.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies, enzyme inhibition assays, and proteomics research.
• Radiopharmaceuticals: Potential precursor for the synthesis of fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging agents.
• Agrochemical Research: Investigated as a building block for novel herbicides and plant growth regulators due to its structural similarity to natural phenylalanine.

Basic Information

Product Name	4-Fluoro-β-Hydroxy-Phenylalanine
CAS No.	322-03-2
Molecular Formula	C9H10FNO3
Molecular Weight	199.18 g/mol
Synonyms	4-Fluoro-3-hydroxy-DL-phenylalanine; 3-Hydroxy-4-fluorophenylalanine; DL-4-Fluoro-3-hydroxyphenylalanine; 4-Fluoro-β-hydroxyphenylalanine; (RS)-2-Amino-3-(4-fluoro-3-hydroxyphenyl)propanoic acid; 4-Fluoro-3-hydroxy-DL-α-amino-benzenepropanoic acid; F-HPA; 4F-HPA
EINECS	Contact for details

Quality Control

Our 4-Fluoro-β-Hydroxy-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Specify D-, L-, or DL-form upon request
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.