Description

2-Fluorobiphenyl is a versatile fluorinated aromatic compound that serves as a critical building block in advanced chemical synthesis. Its value lies in its ability to introduce the biphenyl scaffold with a fluorine substituent, which can significantly alter the electronic properties, metabolic stability, and binding affinity of target molecules. This makes it an essential intermediate for pharmaceutical research, agrochemical development, and the creation of specialty materials for the electronics industry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules where the fluorobiphenyl moiety is a core pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Organic Synthesis & Catalysis: Acts as a ligand or a structural unit in metal-organic frameworks (MOFs) and catalytic systems, leveraging its aromatic stability and fluorine's electronic effects.
• Chemical Research & Development: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	2-Fluorobiphenyl
CAS No.	321-60-8
Molecular Formula	C12H9F
Molecular Weight	172.20 g/mol
Synonyms	2-Fluorodiphenyl; o-Fluorobiphenyl; 1-Fluoro-2-phenylbenzene; Biphenyl-2-fluoro; (2-Fluorophenyl)benzene; 2-FBP; Fluorobiphenyl; 2-Fluor-1,1'-biphenyl
EINECS	206-284-2

Quality Control

Our 2-Fluorobiphenyl is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	34 - 38 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.