Description

4'-Chloro-2,2,2-trifluoroacetophenone is a versatile fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a chloro and a trifluoromethyl group on the acetophenone core, makes it a critical intermediate for the development of complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and other electronic materials.
• Chemical Research & Development: A valuable building block for medicinal chemistry, process chemistry, and the discovery of new chemical entities in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up manufacturing.

Basic Information

Product Name	4'-Chloro-2,2,2-trifluoroacetophenone
CAS No.	321-37-9
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-chlorophenyl)ethanone; 1-(4-Chlorophenyl)-2,2,2-trifluoroethanone; p-Chloro-α,α,α-trifluoroacetophenone; 4-Chloro-α,α,α-trifluoroacetophenone; 4-Chlorophenyl trifluoromethyl ketone; CF3COC6H4Cl-4; 4'-Chloro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.