Description

3'-Chloro-2,2,2-Trifluoroacetophenone is a versatile and high-value fluorinated aromatic ketone building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals due to its reactive trifluoroacetyl and chloro-substituted aromatic ring. It is primarily sought by R&D chemists and process development teams in the fine chemical, pharmaceutical, and agrochemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for improved lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl moiety contributes to efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and developing new synthetic methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for clinical trials and niche market applications.

Basic Information

Product Name	3'-Chloro-2,2,2-Trifluoroacetophenone
CAS No.	321-31-3
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoroacetophenone; 1-(3-Chlorophenyl)-2,2,2-trifluoroethanone; 3-Chloro-α,α,α-trifluoroacetophenone; m-Chloro-α,α,α-trifluoroacetophenone; 3-Chlorophenyl trifluoromethyl ketone; 2,2,2-Trifluoro-1-(3-chlorophenyl)ethanone; 1-(3-Chlorophenyl)-2,2,2-trifluoro-1-ethanone; 3'-Chloro-α,α,α-trifluoroacetophenone
EINECS	206-278-7

Quality Control

Our 3'-Chloro-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.