Description

5-Fluoro-1,3-Isobenzofurandione is a specialized fluorinated organic compound, also known as 5-Fluorophthalic Anhydride. This high-purity intermediate is critical for introducing fluorine atoms into complex molecular structures, enhancing properties like metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical and advanced materials sectors for synthesizing novel active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Polymer Chemistry: Serves as a monomer or modifier in the production of high-performance polymers, such as polyimides and epoxy resins, for electronics and aerospace.
• Liquid Crystal & OLED Materials: A precursor for fluorinated components in display and lighting technologies, contributing to better stability and performance.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D labs for constructing complex heterocycles and fluorinated aromatic systems.
• Dye & Pigment Industry: Employed in the synthesis of specialized fluorinated dyes and pigments for high-value applications.

Basic Information

Item	Details
Product Name	5-Fluoro-1,3-Isobenzofurandione
CAS No.	319-03-9
Molecular Formula	C8H3FO3
Molecular Weight	166.10 g/mol
Synonyms	5-Fluorophthalic Anhydride; 4-Fluorophthalic Anhydride; 5-Fluoroisobenzofuran-1,3-dione; 1,3-Isobenzofurandione, 5-fluoro-; 5-Fluorophthalic Acid Anhydride; 4-Fluorophthalic Acid Anhydride; 5-FPA
EINECS	206-273-5

Quality Control

Every batch of 5-Fluoro-1,3-Isobenzofurandione is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity requirements for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can compromise product integrity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.