Description

2-(Trifluoroacetyl)-3,4-Dihydronaphthalen-1(2H)-One is a high-value fluorinated organic intermediate featuring a fused naphthalene ring system. This compound is prized for its unique reactivity profile, serving as a critical building block in the synthesis of complex molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl ketone moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated naphthalene structure contributes to efficacy.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, aromatic backbone and fluorine content.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex polycyclic frameworks via reactions like Friedel-Crafts acylation, cyclizations, and nucleophilic additions.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the electronic and steric effects of the trifluoroacetyl group in organic transformations.

Basic Information

Product Name	2-(Trifluoroacetyl)-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	318-46-7
Molecular Formula	C₁₂H₉F₃O₂
Molecular Weight	242.19 g/mol
Synonyms	1-(3,4-Dihydro-1(2H)-naphthalenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3,4-dihydro-1(2H)-naphthalenyl)ethanone; 1-(3,4-Dihydronaphthalen-1-yl)-2,2,2-trifluoroethanone; 2-(Trifluoroacetyl)-1-tetralone; α,α,α-Trifluoro-3,4-dihydro-1(2H)-naphthalen-1-yl methyl ketone; 1-Tetralone, 2-(trifluoroacetyl)-; 318-46-7; NSC 403697
EINECS	206-275-6

Quality Control

Our production of 2-(Trifluoroacetyl)-3,4-Dihydronaphthalen-1(2H)-One adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.