Description

Ethanone, 2-Fluoro-1-(4-Fluoro-1-Naphthalenyl)- (9Ci) CAS NO 315-99-1 is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which incorporates two strategically placed fluorine atoms on a naphthalene-acetyl framework, enabling precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates for developing novel active ingredients, particularly in the synthesis of complex fluorinated heterocycles and receptor ligands.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated drug candidates, including kinase inhibitors, anti-cancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in constructing advanced fluorinated scaffolds for new-generation herbicides, fungicides, and pesticides, where fluorine substitution enhances bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing fluorinated organic semiconductors, liquid crystals, and polymers with tailored optical and electronic properties.
• Chemical Biology & Probe Development: Employed in creating fluorescent tags, photoaffinity labels, and other molecular probes that leverage the naphthalene fluorophore and the reactivity of the ketone group.
• Academic & Contract Research: A valuable reagent for methodological studies in cross-coupling reactions, fluorination chemistry, and the synthesis of polycyclic aromatic compounds in university and CRO laboratories.

Basic Information

Product Name	Ethanone, 2-Fluoro-1-(4-Fluoro-1-Naphthalenyl)- (9Ci)
CAS No.	315-99-1
Molecular Formula	C₁₂H₈F₂O
Molecular Weight	206.19 g/mol
Synonyms	2-Fluoro-1-(4-fluoronaphthalen-1-yl)ethan-1-one; 1-(4-Fluoro-1-naphthyl)-2-fluoroethanone; 4'-Fluoro-α-fluoro-1-naphthyl methyl ketone; 1-Acetyl-4-fluoronaphthalene, 2-fluoro derivative; α,4-Difluoro-1-naphthyl methyl ketone; 2-Fluoro-1-(4-fluoro-1-naphthyl)ethanone; 4-Fluoro-1-naphthalenyl 2-fluoroethyl ketone
EINECS	Contact for details

Quality Control

Every batch of Ethanone, 2-Fluoro-1-(4-Fluoro-1-Naphthalenyl)- (9Ci) is produced and controlled under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.