Description

(4-Fluoro-Phenyl)-Phosphonic Acid Diethyl Ester is a high-purity organophosphorus compound serving as a critical synthetic intermediate. Its value lies in the unique reactivity of the phosphonate ester group, which enables efficient carbon-carbon and carbon-heteroatom bond formation under mild conditions. This chemical is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Precursor: Serves as a starting material for synthesizing specialized phosphonate-based ligands for metal catalysis.
• Material Science Research: Employed in the development of flame retardants, metal-chelating agents, and specialty polymers.
• Cross-Coupling Reactions: Acts as a reagent in Horner-Wadsworth-Emmons (HWE) olefination and other palladium-catalyzed coupling processes.
• Chemical Biology Probes: Utilized in the design of enzyme inhibitors and molecular probes for biochemical research.

Basic Information

Product Name	(4-Fluoro-Phenyl)-Phosphonic Acid Diethyl Ester
CAS No.	310-40-7
Molecular Formula	C10H14FO3P
Molecular Weight	232.19 g/mol
Synonyms	Diethyl (4-Fluorophenyl)phosphonate; (p-Fluorophenyl)phosphonic Acid Diethyl Ester; 4-Fluorobenzylphosphonic Acid Diethyl Ester; Diethyl P-(4-Fluorophenyl)phosphonate; Phosphonic Acid, P-(4-Fluorophenyl)-, Diethyl Ester; Diethyl 4-Fluorobenzylphosphonate; (4-Fluorophenyl)phosphonic Acid Diethyl Ester
EINECS	206-212-8

Quality Control

Our (4-Fluoro-Phenyl)-Phosphonic Acid Diethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to minimize moisture absorption and exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.