Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester pinacol ester protecting group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex bioactive molecules. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel drug candidates and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a pivotal building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality is essential for forming carbon-carbon bonds under mild conditions, a cornerstone of modern synthetic chemistry.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic architectures.
• Material Science: A precursor for creating organic electronic materials, ligands for catalysts, and novel polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to outsourcing partners for custom synthesis and scale-up projects.

Basic Information

Item	Details
Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	2828446-91-7
Molecular Formula	C15H23BClNO2
Molecular Weight	295.61 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline hydrochloride; 1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline hydrochloride; 6-Tetrahydroisoquinoline boronic acid pinacol ester hydrochloride; 6-BPin-THIQ HCl; 6-(Pinacolboron)tetrahydroisoquinoline HCl
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.