Description

1,3,2-Dioxaborolane, 2-[7-Fluoro-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-3-[[Tris(1-Methylethyl)Silyl]Oxy]-1-Naphthalenyl]-4,4,5,5-Tetramethyl- is a sophisticated, multi-functional organoboron reagent featuring dual triisopropylsilyl (TIPS) protecting groups. This compound is engineered as a critical advanced synthetic intermediate for constructing complex molecular architectures, particularly in pharmaceutical discovery and materials science. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, agrochemical, and advanced materials sectors who require high-purity, structurally complex building blocks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for fluorinated and boron-containing drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a highly functionalized boronic ester partner for palladium-catalyzed cross-coupling, enabling the formation of complex biaryl and heterobiaryl structures.
• Organic Light-Emitting Diode (OLED) Materials Research: Used in the development of novel electron-transport materials or emissive layer components due to its fused aromatic and boron-containing structure.
• Agrochemical Synthesis: Intermediate for creating new-generation herbicides, fungicides, or insecticides with enhanced efficacy and selectivity.
• Polymer and Materials Science: A monomer or functionalization agent for creating specialty polymers with tailored electronic or optical properties.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 2-[7-Fluoro-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-3-[[Tris(1-Methylethyl)Silyl]Oxy]-1-Naphthalenyl]-4,4,5,5-Tetramethyl-
CAS No.	2791277-41-1
Molecular Formula	C₃₄H₅₂BFO₃Si₂
Molecular Weight	582.75 g/mol
Synonyms	2-(7-Fluoro-8-((triisopropylsilyl)ethynyl)-3-((triisopropylsilyl)oxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Naphthaleneboronic acid, 7-fluoro-8-[2-[tris(1-methylethyl)silyl]ethynyl]-3-[[tris(1-methylethyl)silyl]oxy]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; TIPS-protected fluoronaphthyl boronic ester; Bis-TIPS fluoronaphthyl pinacol boronate; (7-Fluoro-8-(triisopropylsilylethynyl)-3-(triisopropylsilyloxy)-1-naphthyl)boronic acid pinacol ester; Advanced fluorinated boronic ester intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by a comprehensive suite of analytical techniques including NMR (1H, 13C, 19F, 11B), HPLC, and GC-MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.