Description

3-Pyrrolidinepropanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-, Methyl Ester, (αs,3R)- is a high-purity, stereochemically defined chiral building block critical for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel pharmaceuticals, particularly in constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, especially in therapeutic areas requiring complex peptidomimetics or constrained amino acid analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and functional groups into target molecules.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Peptidomimetic Synthesis: Integral for constructing non-natural amino acid derivatives and pseudopeptide backbones used in drug design to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Pyrrolidinepropanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-, Methyl Ester, (αs,3R)-
CAS No.	2768833-99-2
Molecular Formula	C14H24N2O5
Molecular Weight	300.35 g/mol
Synonyms	(3R)-3-[[(tert-Butoxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoic acid methyl ester; (αS,3R)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-oxo-3-pyrrolidinepropanoic acid methyl ester; Methyl (αS,3R)-α-[(tert-butoxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoate; Boc-protected pyrrolidine amino acid ester; Chiral pyrrolidone derivative; tert-Butyloxycarbonyl amino acid methyl ester; N-Boc-3-pyrrolidinepropanoate derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, and NMR to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP manufacturing needs with appropriate documentation and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.